Project Details

Transcutaneous Spinal Cord Stimulation to Improve Lower Limb Function in Children with Spina Bifida

Anders Asp, PhD

Summary

BACKGROUND: Spina bifida is a congenital defect that disrupts spinal cord development, often leading to severe neurological impairments such as paralysis and mobility loss. Current treatments for children with spina bifida are limited, with no therapies effectively addressing progressive mobility decline GAP: A critical challenge is the lack of tools to understand patient-specific disruptions in neuromotor connectivity, which hinders personalized treatment approaches. HYPOTHESIS: This study hypothesizes that transcutaneous spinal cord stimulation (TS) will enable motor-evoked responses to characterize patient-specific neuromotor connectivity and that closed-loop TS will enhance lower limb strength and coordination in children with spina bifida. METHODS: This two-year study will enroll 32 children aged 5–18 with spina bifida at Mayo Clinic. Using a closed-loop TS protocol, the study will evaluate changes in muscle strength, spasticity, and gait outcomes, comparing pre- and post-treatment measures through advanced statistical analyses. RESULTS: Pending. IMPACT: This research aims to improve diagnostics and therapeutic outcomes for children with spina bifida by providing insights into their unique neuromotor profiles. Findings may lead to advancements in spinal cord stimulation therapies, ultimately enhancing motor function and quality of life for affected children. Website Link: www.linkedin.com/in/anders-asp-5a3041157